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Buprenorphine , a partial agonist available in formulations such as Suboxone (combined with naloxone), Sublocade, and Brixadi, presents a lower risk of overdose and has become a mainstay of outpatient care

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Some Phase 3 trial sites are in Asia (REDEFINE 5, REDEFINE 6) but no regulatory approvals have been announced as of June 2026

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